Over the course of his three-decade career, he has directed films such as 'Odayil Ninnu,' 'Anubhavangal Palichakal,' 'Oppol,' 'Aranazhikaneeram,' 'Achanum Bappayum,' and 'Panitheeratha Veedu,' among others. He has directed nearly 60 films in Tamil, Telugu, Hindi, and Malayalam, among other languages. KS Sethumadhavan has received ten national awards and many Kerala state cinema awards, as well as the coveted J C Daniel Award, the Kerala government's highest honour in the film industry, in 2009. His most recent film was 'Venalkinavukal,' which was based on a script by Jnanpith laureate M T Vasudevan Nair and released in 1991.