Kraven the Hunter: This classic Spider-Man antagonist has been a fan favorite for years. Kraven's obsession with hunting Spider-Man could lead to an intense and personal confrontation, showcasing the hero's survival instincts.
Norman Osborn (Green Goblin): The enigmatic Norman Osborn has been pivotal in Spider-Man's life. As a powerful businessman and the sinister Green Goblin, his presence would undoubtedly add complexity to the narrative.
Mysterio: With the multiverse concept introduced in previous MCU instalments, Mysterio could make a surprising return. His illusions and manipulations would keep both Spider-Man and the audience guessing.
Doc Ock (Doctor Octopus): A fan-favorite villain, Doc Ock's scientific brilliance and mechanical tentacles could create a formidable challenge for Spider-Man, especially if he's portrayed in a new light.
Scorpion: While teased in previous films, Scorpion's transformation into a full-fledged villain could be explored, presenting a physical and psychological threat to Spider-Man.
Sandman: Another character with layers of complexity, Sandman's potential return could delve into his moral struggles and his place in the greater MCU.
Kingpin: A crime lord with ties to many Marvel heroes, Kingpin's influence could extend beyond Spider-Man's world, connecting various storylines within the MCU.
Venom: Although Venom has his own separate cinematic universe, the possibility of a crossover could bring the iconic anti-hero into Spider-Man's world, setting the stage for a monumental clash.