The number of active cases increased to 4,10,353 and accounted for 1.29 per cent of the total infections, while the national Covid-19 recovery rate rose to 97.37 per cent.
In the past 24 hours, India recorded 42,982 fresh Covid-19 cases, as per health ministry data.
The death toll climbed to 4,25,757 with 562 fatalities. The number of active cases increased to 4,10,353 and accounted for 1.29 per cent of the total infections, while the national Covid-19 recovery rate rose to 97.37 per cent.
An increase of 723 cases has been recorded in the active COVID-19 caseload in a span of 24 hours.
India's COVID-19 tally had crossed the 20-lakh mark on August 7, 30 lakh on August 23, 40 lakh on September 5 and 50 lakh on September 16.It went past 60 lakh on September 28,
70 lakh on October 11, crossed 80 lakh on October 29, 90 lakh on November 20 and surpassed the one-crore mark on December 19.India crossed the grim milestone of two crore on May 4 and three crore on June 23.
As many as 16,64,030 tests were conducted on Wednesday taking the total cumulative tests conducted so far for detection of COVID-19 in the country to 47,48,93,363.
The daily positivity rate was recorded at 2.58 per cent and the weekly positivity rate was recorded at 2.37 per cent, according to the ministry.
The number of people who have recuperated from the disease surged to 3,09,74,748, while the case fatality rate stands at 1.34 per cent, the data stated.
Cumulative vaccine doses administered so far has reached 48.93 crore under the nationwide vaccination drive.
The 533 new fatalities include 195 from Maharashtra and 108 from Kerala.
A total of 4,26,290 deaths have been reported so far in the country including 1,33,410 from Maharashtra, 36,680 from Karnataka, 34,197 from Tamil Nadu, 25,058 from Delhi, 22,767 from Uttar Pradesh, 18,180 from West Bengal and 17,211 from Kerala.
The ministry stressed that more than 70 per cent of the deaths occurred due to comorbidities.
"Our figures are being reconciled with the Indian Council of Medical Research," the ministry said on its website, adding that state-wise distribution of figures is subject to further verification and reconciliation.
With PTI inputs