Sweden came from behind to beat Spain and leapfrog the visitors for first place.
Carlos Soler scored five minutes into his debut for Spain to put the visitors in front, but Aleksander Isak leveled seconds later.
Viktor Claesson put Sweden ahead for good in the 57th. Only some desperate defending by Spain's defenders denied Isak a chance to add another goal on the counterattack.
Sweden has a perfect nine points from three games, while Spain fell to second place with seven points from four games.
Kosovo moved up to third after beating Georgia 1-0.
GROUP C
Mancini had recalled all the fit players from his European Championship-winning squad for the three World Cup qualifiers and nine of the starting lineup against Bulgaria started the Euro 2020 final against England in July.
The Azzurri dominated from the start and took the lead in the 16th minute when Chiesa played a one-two with Ciro Immobile before firing into the bottom right corner.
Italy seemed fully in control and had several chances to extend its lead before Bulgaria leveled five minutes from halftime against the run of play. Kiril Despodov burst down the left before sending in a low pass for Iliev to sweep past Gianluigi Donnarumma.
Italy moved four points ahead of second-place Switzerland, which has played two matches less.
Lithuania is bottom of the group with zero points and lost 4-1 at home to Northern Ireland.
GROUP E
Romelu Lukaku scored twice as top-ranked Belgium came from an early goal down to beat Estonia 5-2 and stay atop Group E.