Nick Kyrgios ended world number 1 Daniil Medvedev's US Open reign with a four-set win on Monday. The 23rd seed Aussie defeated the defending champion from Russia 7–6 (13–11), 3–6, 6–3, 6–2 in their fourth round match. Norway's Casper Ruud (5), Italy's Matteo Berrettini (13), and Russia's Karen Khachanov (27) also won their respective matches to enter the quarter-finals. In women's singles, Tunisia's Ons Jabeur (5), USA's Coco Gauff (12), France's Caroline Garcia (17), and Australia's Ajla Tomljanovic won their respective matches.