One of the hottest synthetic peptides to make waves recently is the Insulin-like Growth Factor 1 Long R3, or IGF1 LR3 for short.
This peptide has made a name for itself rather quickly in the fitness and bodybuilding communities, becoming well-known for its potent effects that mimic anabolic steroids.
It has shown an incredible ability to help boost muscle growth, improve recovery times, and enhance general physical performance.
In this article, we’re going to explore everything about IGF-1 LR3, from exactly what it is to how its mechanism of action works.
We’ll dig into the purported benefits, what the clinical research is saying, what side effects users should look out for, and even dosage and usage considerations.
What is IGF-1 LR3?
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IGF-1 LR3 is a fully synthetic peptide that bears an incredibly close resemblance to IGF1, a hormone that the body produces naturally.
IGF-1 is critical for things like growth and development, and even modulating the growth, differentiation, and survival of cells.
The “LR3” variant has been specifically created by engineers to have a longer half-life than endogenous IGF1.
With a longer half-life, IGF-1 LR3 can remain active in the body for a much longer period, giving the user prolonged benefits.1
This LR3 modification centers around changing the amino acid sequence of IGF1, stretching out its half-life while also enhancing its binding affinity for IGF1, resulting in it being more effective in stimulating growth and metabolic processes.
IGF-1 LR3 is relatively widely used in the bodybuilding and hypertrophy communities for its ability to promote intense muscle growth, boost metabolism, and accelerate recovery rates.
In addition to these performance-enhancing properties, IGF-1 LR3 has also been clinically evaluated for its potential therapeutic applications.
These investigations show that it had treatment potential for growth deficiencies, muscle wasting diseases, and even some metabolic conditions.
Mechanism of Action
The mechanism of action for IGF-1 LR3 is relatively sophisticated and mimics the action of natural IGF1 but with enhanced potency and longevity.
Insulin-like growth factor 1 is an endogenous hormone created mainly in the liver in response to growth hormone stimulation.
IGF-1 plays a foundational role in the survival, growth, and differentiation of cells, and the LR3 variant has been engineered to have a far longer half-life.
IGF-1 LR3 can remain active in the body for up to 20-30 hours, compared to the relatively short duration of natural IGF1.
This modification to the half-life requires altering the amino acid sequence to stop it from binding to other proteins in the blood that would simply deactivate the compound.
It binds to IGF1 receptors on the surface of cells, which causes a cascade of intracellular signaling pathways.
One of the many pathways that are activated is the PI3K-Akt pathway, which is instrumental in synthesizing proteins and inhibits further protein degradation.
This leads to measurable hypertrophy, or enlargement of the muscle fibers, due to the accumulation of muscle cells.2
As a result, IGF-1 LR3 has the potential to be a powerful agent for muscle growth.
Not only that, but IGF-1 LR3 also boosts glucose uptake into the cells, specifically muscle cells, while also reducing blood glucose levels.
This contributes to an improved metabolic efficiency, which in turn means more effective energy utilization.
This is invaluable for athletes and bodybuilders since it helps sustain needed energy levels during high-intensity physical activity or training.
Additionally, IGF-1 LR3 encourages cell proliferation in satellite cells, which are vital for repairing damaged muscle tissue and regenerating muscle following an injury.
IGF-1 LR3 also has a surprising role in the body’s metabolism of fat cells.
It increases lipolysis, or the breakdown of fat, and even inhibits lipogenesis, where the body forms new fat cells.
This valuable dual action helps reduce body fat while also preserving lean muscle mass, which is tremendously helpful for individuals in a cutting phase.
Benefits of IGF-1 LR3
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IGF-1 LR3 is renowned for the benefits that it’s been able to demonstrate, and it has become a highly sought-after peptide across the fitness, bodybuilding, and medical spaces.
One of the primary benefits of IGF-1 LR3 is the ability to affect significant muscle growth and hypertrophy.
By activating the IGF1 receptors and activating the PI3K-Akt signaling framework, IGF-1 LR3 can enhance protein synthesis and inhibit protein degradation for much longer than IGF1.3
This action helps the growth of muscle fibers, which contributes to increased muscle mass and more raw power felt during workouts.
Athletes and bodybuilders who use IGF-1 LR3 as a training supplement find it helps them reach greater measured muscle size and greater levels of strength.
IGF-1 LR3 is also radically effective for elevating muscle recovery and repair.
This is due to the IGF-1 LR3 peptide stimulating both the differentiation and proliferation of satellite cells.
Satellite cells are essential elements of muscle regeneration.
With the enhanced activation of these cells for longer periods, IGF-1 LR3 magnifies the body’s natural rate of damaged tissue repair.4
This hastened rate of damage recovery means less recovery time between workouts, and more time spent training intensely.
Another notable benefit of using IGF-1 LR3 is the impact it can have on the body’s natural metabolic state.
Since IGF1 LR3 enhances cellular glucose uptake, specifically in muscle cells, it helps to lower blood glucose levels which works to improve insulin sensitivity.
This elevated insulin sensitivity and glucose metabolism ensures that lean muscle tissue has a steady supply of energy during exercise and exertion.
More energy during exercise means more endurance and higher levels of general performance.
Also, the ability to stop lipogenesis and elevate lipolysis means the peptide works twice to reduce body fat, while also stopping the loss of existing muscle.
For those looking to shift body composition during a cutting phase, or who are just looking for a lean and defined physique, IGF1 LR3 can be a valuable tool.
The potent anabolic effects of IGF-1 LR3 directly translate into more strength and higher levels of general physical performance.
With explosive hypertrophy and speedy muscle recovery, IGF-1 LR3 helps individuals lose more weight and stick to much more intense workouts.
This marked boost in strength is not only beneficial for bodybuilders and athletes focused on strength, but for athletes who focus on endurance as well, who also need muscle power.
Another benefit of IGF-1 LR3 that has been explored is the potential for regenerative and even anti-aging properties.
As people age, the production of natural growth factors, like IGF1, decreases.
This decrease in natural growth factors is a natural precursor for lower muscle mass, decreased strength, and lower overall vitality.
Incorporating IGF-1 LR3 into your fitness supplement regimen can help counter declines due to aging, by promoting easier muscle growth, improving metabolic function, and enhancing overall tissue repair.5
IGF-1 LR3 also has significant benefits for bone density and joint health as well.
It stimulates the production and proliferation of osteoblasts, which are at the core of bone formation.6
Additionally, its ability to boost tissue repair while also reducing inflammation can support joint health significantly.7
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Clinical Studies and Research
Looking at the clinical research into IGF-1 LR3, we can get some truly significant insights into the potential benefits and therapeutic applications.
Despite much of the existing body of research being focused on animal models, the early results are promising and help lay a substantial foundation for potential human studies.
One of the most notable studies focused on the effects of IGF1 LR3 on muscle growth and repair in rats.8
In this study, researchers found that IGF-1 LR3 caused substantial increases in muscle mass, improved muscle fiber size, and more, showcasing its powerful anabolic qualities.
That same study also highlighted enhanced recovery and reduced incidence of muscle damage following intense activity.
Another study focused on the metabolic effects of IGF-1 LR3, where it was shown to improve sensitivity to insulin and glucose uptake ability in animal models.9
There was also a study done to dig into IGF1 LR3’s effects on bone health.
Here, it was shown that IGF-1 LR3 stimulated osteoblast proliferation while also increasing bone density in animal models.10
Clinical trials with humans are still incredibly limited, but initial studies suggest that IGF-1 LR3 could have therapeutic benefits for individuals with growth conditions and muscle-wasting diseases.
Potential Side Effects
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Even though there is a long list of benefits to IGF1 LR3, there are some potential side effects that anyone considering use should take into account.
First and foremost is the peptide’s impact on blood glucose levels, which could lead to hypoglycemia.
Symptoms of hypoglycemia include becoming dizzy, feeling more fatigued than normal, and a state of confusion.
To mitigate this risk, all users should monitor their blood sugar levels and adjust their dosages accordingly.
Another potential side effect is organ growth.
Since a primary effect of IGF-1 LR3 is cellular growth and proliferation, there is the risk of developing adverse organ enlargement.
This can be a particularly worrisome side effect for anyone with a predisposition to cancer since elevated cell proliferation could exacerbate the growth of existing cancer cells.
Usage and Dosage Guidelines
Determining the proper dosage of IGF-1 LR3 is an important part of achieving the optimal benefits.
In most cases, IGF-1 LR3 is given through injection, which allows a direct but controlled entry into the bloodstream.
The dosage for IGF1 LR3 will generally range from 20 mcg to 50 mcg per day.
The best advice for anyone just starting is to start at the low end and assess your response and tolerance.
IGF-1 LR3 should only be administered once per day, ideally before or immediately post-workout to make the most of the anabolic effects.
Usage cycles should be used to prevent desensitization, with the typical cycle lasting 4 to 6 weeks, with an equal period of disuse.
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Who Should Avoid IGF-1 LR3?
Even though there are many benefits to IGF-1 LR3, it’s not suitable for everyone.
Pregnant or breastfeeding women should avoid IGF1 LR3 due to the potential side effects.
Also, those with cancer, or a history of cancer, should avoid IGF-1 LR3 due to the cell proliferation effects.
Finally, those with pre-existing liver or kidney conditions should avoid IGF-1 LR3, since it can put high levels of stress on these systems.
Final Thoughts
With benefits and research like IGF-1 LR3, it’s no surprise that it has become as popular as it has.
Users can expect big improvements in muscle growth, recovery, and metabolism, but there are also some serious side effects to look out for.
If you’re considering adding IGF-1 LR3 to your supplement plan, be sure you consult with a healthcare professional.
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References
Anderson LJ, Tamayose JM, Garcia JM. Use of growth hormone, IGF-I, and insulin for anabolic purpose: Pharmacological basis, methods of detection, and adverse effects. Mol Cell Endocrinol. 2018 Mar 15;464:65-74. doi: 10.1016/j.mce.2017.06.010. Epub 2017 Jun 9. PMID: 28606865; PMCID: PMC5723243.
Philippou A, Barton ER. Optimizing IGF-I for skeletal muscle therapeutics. Growth Horm IGF Res. 2014 Oct;24(5):157-63. doi: 10.1016/j.ghir.2014.06.003. Epub 2014 Jun 19. PMID: 25002025; PMCID: PMC4665094.
Tomas FM, Chandler CS, Coyle P, Bourgeois CS, Burgoyne JL, Rofe AM. Effects of insulin and insulin-like growth factors on protein and energy metabolism in tumour-bearing rats. Biochem J. 1994 Aug 1;301 ( Pt 3)(Pt 3):769-75. doi: 10.1042/bj3010769. PMID: 8053901; PMCID: PMC1137054.
Garoufalia Z, Papadopetraki A, Karatza E, Vardakostas D, Philippou A, Kouraklis G, Mantas D. Insulin-like growth factor-I and wound healing, a potential answer to non-healing wounds: A systematic review of the literature and future perspectives. Biomed Rep. 2021 Aug;15(2):66. doi: 10.3892/br.2021.1442. Epub 2021 Jun 8. PMID: 34155450; PMCID: PMC8212444.
Miescher I, Rieber J, Calcagni M, Buschmann J. In Vitro and In Vivo Effects of IGF-1 Delivery Strategies on Tendon Healing: A Review. Int J Mol Sci. 2023 Jan 25;24(3):2370. doi: 10.3390/ijms24032370. PMID: 36768692; PMCID: PMC9916536.
Locatelli V, Bianchi VE. Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis. Int J Endocrinol. 2014;2014:235060. doi: 10.1155/2014/235060. Epub 2014 Jul 23. PMID: 25147565; PMCID: PMC4132406.
Guijarro LG, Cano-Martínez D, Toledo-Lobo MV, Salinas PS, Chaparro M, Gómez-Lahoz AM, Zoullas S, Rodríguez-Torres R, Román ID, Monasor LS, Ruiz-Llorente L, Del Carmen Boyano-Adánez M, Guerra I, Iborra M, Cabriada JL, Bujanda L, Taxonera C, García-Sánchez V, Marín-Jiménez I, Acosta MB, Vera I, Martín-Arranz MD, Mesonero F, Sempere L, Gomollón F, Hinojosa J, Alvarez-Mon M, Gisbert JP, Ortega MA, Hernández-Breijo B, On Behalf Of The Predicrohn Study Group From Geteccu. Relationship between IGF-1 and body weight in inflammatory bowel diseases: Cellular and molecular mechanisms involved. Biomed Pharmacother. 2021 Dec;144:112239. doi: 10.1016/j.biopha.2021.112239. Epub 2021 Sep 30. PMID: 34601192.
Meyer NA, Barrow RE, Herndon DN. Combined insulin-like growth factor-1 and growth hormone improves weight loss and wound healing in burned rats. J Trauma. 1996 Dec;41(6):1008-12. doi: 10.1097/00005373-199612000-00011. PMID: 8970554.
Assefa B, Mahmoud AM, Pfeiffer AFH, Birkenfeld AL, Spranger J, Arafat AM. Insulin-Like Growth Factor (IGF) Binding Protein-2, Independently of IGF-1, Induces GLUT-4 Translocation and Glucose Uptake in 3T3-L1 Adipocytes. Oxid Med Cell Longev. 2017;2017:3035184. doi: 10.1155/2017/3035184. Epub 2017 Dec 20. PMID: 29422987; PMCID: PMC5750484.
Bailes J, Soloviev M. Insulin-Like Growth Factor-1 (IGF-1) and Its Monitoring in Medical Diagnostic and in Sports. Biomolecules. 2021 Feb 4;11(2):217. doi: 10.3390/biom11020217. PMID: 33557137; PMCID: PMC7913862.
Disclaimer: The above is a contributor post, the views expressed are those of the contributor and do not represent the stand and views of Outlook Editorial
