Peptic ulcers, characterized by acid-induced lesions in the stomach and duodenum, are a significant medical concern with a global impact. In the United States, the prevalence of physician-diagnosed peptic ulcer disease (PUD) was 10 percent in 1990, with approximately 500,000 new cases reported annually. However, a positive trend has emerged, showing a decline in the risk of mortality and the need for hospitalizations related to PUD worldwide. Several factors contribute to this decline, notably the successful treatment of Helicobacter pylori (H. pylori) infections and improved hygiene practices.