It has been 40 years since the first case of AIDS was reported in San Francisco. Since then, there has been huge progress in HIV prevention, treatment, and care to address this epidemic. NGOs, governments, corporates, communities, individuals have ever since the 1980s worked on increasing awareness on HIV and advocating action to address this deadly disease. By June 2021, 28.2 million people had access to HIV treatment, up from 7.8 million in 2010, although progress can be made faster with higher investments and a bigger role of all key players especially now seeing high vulnerability amid the COVID-19 Pandemic.